Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation.

Correspondence to: Sadik Esener, [email protected]; Joseph Wang, [email protected]. †These authors contributed equally to this work. Supporting information for this article is available on the WWW under http://www.angewandte.org or from the author. NIH Public Access Author Manuscript Angew Chem Int Ed Engl. Author manuscript; available in PMC 2013 July 23. Published in final edited form as: Angew Chem Int Ed Engl. 2012 July 23; 51(30): 7519–7522. doi:10.1002/anie.201201902. N IH PA Athor M anscript N IH PA Athor M anscript N IH PA Athor M anscript Acoustic droplet vaporization of perfluorocarbon-loaded microbullets triggered by an ultrasound pulse provides the necessary force to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery.